Alpha-Ketoglutarate: Physiological Functions and Applications
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چکیده
منابع مشابه
Alpha-Ketoglutarate: Physiological Functions and Applications.
Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism. It is a nitrogen scavenger and a source of glutamate and glutamine that stimulates protein synthesis and inhibits protein degradation in muscles. AKG as a precursor of glutamate and glutamine is a central metabolic fuel for cells of the gastrointestinal tract as ...
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Alpha-ketoglutarate (AKG) is an intermediate of the Krebs cycle which bridges amino acid metabolism with glucose oxidation in animals. Of particular interest is the conversion of AKG into glutamate by mitochondrial glutamate dehydrogenase in the gastrointestinal tract where glutamate has multiple physiological functions (including regulation of cell function, neurotransmission, and gastric empt...
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(2) (3) freundii, strain F920A. The enzymatic activity of isocitric dehydrogenase was followed in the Beckman DU spectrophotometer. Reversibility of the reactions was determined in two ways. (a) Spectrophotometrically by observing the reoxidation of reduced triphosphopyridine nucleotide on the addition of carbon dioxide and an excess of a-ketoglutarate in the presence of isocitric dehydrogenase...
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ژورنال
عنوان ژورنال: Biomolecules & Therapeutics
سال: 2016
ISSN: 2005-4483,1976-9148
DOI: 10.4062/biomolther.2015.078